Dr. Satchin Panda: Intermittent Fasting to Improve Health, Cognition & Longevity
In this episode, my guest is Satchin Panda, PhD, professor and the director of the Regulatory Biology Laboratories at the Salk Institute for Biological Studies. We discuss his lab’s discovery that “time-restricted eating” (TRE) aka intermittent fasting, is beneficial effects for metabolic health and longevity. Dr. Panda explains how TRE, and also longer fasts, can positively impact obesity, diabetes, cardiovascular health, age-related chronic diseases, and improve mood and cognitive performance. He also describes how the timing of eating, light exposure and exercise that ~50% of all people engage in, negatively impacts their health and explains how specific simple adjustments to these can positively shift their subjective feelings of health and biomarkers of cardiovascular function, glucose regulation and metabolism. We discuss how our circadian behaviors, which include our patterns of eating, sleeping and socializing, have an enormous impact on our biology, mood and health and how by simply confining our calorie consumption to a semi-regular daily window, can positively impact our physical health, mental health and longevity.
Death is defined as the irreversible cessation of circulatory, respiratory or brain activity. Many peripheral human organs can be transplanted from deceased donors using protocols to optimize viability. However, tissues from the central nervous system rapidly lose viability after circulation ceases1,2, impeding their potential for transplantation.
Like most people, you probably wake up, get hungry for meals and doze off in bed at about the same time every day. If you've ever experienced jet lag or pulled an all-nighter, you know that this schedule can easily be thrown off-kilter.
We study the molecular bases of circadian timekeeping mechanism in mammals. We intend to understand the mechanism of light perception by specialized light sensitive ganglion cells of the retina which photo-entrain the master circadian oscillator resident in the hypothalamic SCN.
Late sleep timing is associated with health problems. Stothard et al. show that the human circadian clock is timed later in modern society, especially after the weekend, compared to natural light-dark cycles.
Access to electric light might have shifted the ancestral timing and duration of human sleep. To test this hypothesis, we studied two communities of the historically hunter-gatherer indigenous Toba/Qom in the Argentinean Chaco.